Blar i Bergen Open Research Archive på forfatter "Jacobsen, Rhian Gaenor"

Viser treff 1-4 av 4

    • Class I Phosphoinositide 3-Kinase PIK3CA/p110α and PIK3CB/p110β Isoforms in Endometrial Cancer 

      Mazloumi Gavgani, Fatemeh; Arnesen, Victoria Smith; Jacobsen, Rhian Gaenor; Krakstad, Camilla; Høivik, Erling Andre; Lewis, Aurelia Eva (Peer reviewed; Journal article, 2018-12-07)
      The phosphoinositide 3-kinase (PI3K) signalling pathway is highly dysregulated in cancer, leading to elevated PI3K signalling and altered cellular processes that contribute to tumour development. The pathway is normally ...

    • DNA Topoisomerase IIα contributes to the early steps of adipogenesis in 3T3-L1 cells 

      Jacobsen, Rhian Gaenor; Gavgani, Fatemeh Mazloumi; Mellgren, Gunnar; Lewis, Aurelia Eva (Peer reviewed; Journal article, 2016-07-09)
      DNA topoisomerases (Topo) are multifunctional enzymes resolving DNA topological problems such as those arising during DNA replication, transcription and mitosis. Mammalian cells express 2 class II isoforms, Topoisomerases ...

    • Polyphosphoinositides in the nucleus: Roadmap of their effectors and mechanisms of interaction 

      Jacobsen, Rhian Gaenor; Gavgani, Fatemeh Mazloumi; Edson, Amanda Jayne; Goris, Marianne; Altankhuyag, Altanchimeg; Lewis, Aurelia Eva (Peer reviewed; Journal article, 2019)
      Biomolecular interactions between proteins and polyphosphoinositides (PPIn) are essential in the regulation of the vast majority of cellular processes. Consequently, alteration of these interactions is implicated in the ...

    • SAF-A/hnRNP U binds polyphosphoinositides via a lysine rich polybasic motif located in the SAP domain 

      Edson, Amanda Jayne; Jacobsen, Rhian Gaenor; Lewis, Aurelia Eva (Journal article; Peer reviewed, 2023)
      Polyphosphoinositides (PPIn) play essential functions as lipid signalling molecules and many of their functions have been elucidated in the cytoplasm. However, PPIn are also intranuclear where they contribute to chromatin ...